Penicisimpins A-C, three new dihydroisocoumarins from Penicillium simplicissimum MA-332, a marine fungus derived from the rhizosphere of the mangrove plant Bruguiera sexangula var. rhynchopetala

摘要

Three new dihydroisocoumarin derivatives, penicisimpins A-C (1-3), were isolated and identified from Penicillium simplicissimum MA-332, a fungus derived from the rhizosphere of the marine mangrove plant Bruguiera sexangula var. rhynchopetala. Their structures and absolute configurations were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment. Compounds 1-3 exhibited brine shrimp (Artemia salina) lethality as well as broad-spectrum antimicrobial activities. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.