胚胎发育过程中的DNA甲基化作用

摘要

Normal development of mammals depends on accurate function of epigenetic regulation, such as genome-wide DNA methylation reprogramming in the primordial germ cells and in the early embryo. DNA methylation in embryonic development was closely related with genomic imprinting, regulation of gene expression and morphogenesis of cells and embryos. It is of significance to clarify the mechanism and function of DNA methylation for research on mammalian ontogeny and human disease.%哺乳动物的正常发育取决于表观遗传学调控机制准确无误地运行.其中尤为重要的是发生在原生殖细胞和胚胎中的基因组范围内的DNA甲基化模式重排等表现遗传学修饰.胚胎发育过程中的DNA甲基化作用与基因印记的建立、基因表达的调控以及细胞和胚胎的形态建成都密切相关.DNA甲基化发生机制和功能的阐明将对哺乳动物个体发育与人类疾病研究有重要意义.