导流杂交技术检测中原地区女性人乳头瘤病毒感染情况

摘要

Objective To investigate the infection rate of human papillomavirus ( HPV ), the distribution of HPV subtypes and the relationship between HPV infection and age. Methods Polymerase chain reaction ( PCR ) and channelization hybridization were used to detect the subtypes of HPV among 11 861 women. Results The infection rate of HPV was 29. 0%. The predominant subtype was high risk-HPV16 ( 8. 3% ), followcd by low risk-HPV6 ( 6. 0% ), low risk-HPV11 (5.5% ), high risk-HPV52 ( 4. 6% ) and high risk-HPV58 (3.8% ). The; infection rate of HPV was statistically significant in different age groups ( P < 0. 01 ). The highest infection rate distributed in 20-30 years old group ( 42. 8% ), followed by 30-40 years old group (25.7% ), more; than 50 years old group (23.2% ) and 40-50 years old group ( 17.9% ). Conclusions The predominant subtype of HPV infection is HPV16, and the 20-30 years old women have the highest infection rate in Chinese central plains.%目的 研究中原地区人乳头瘤病毒(HPV)感染率及亚型分布,探讨HPV感染与年龄的关系.方法采用聚合酶链反应(PCR)及导流杂交技术对11 861例就诊的女性进行HPV分型检测.结果 HPV感染率为29.0%,其中高危型HPV16感染率最高(8.3%),其次依次为低危型HPV6(6.0%)、低危型HPV11(5.5%)、高危型HPV52(4.6%)、高危型HPV58(3.8%).不同年龄组间HPV感染率差异有统计学意义(P<0.01),20~30岁组感染率(42.8%)最高,其次为30~40岁组(25.7%)和50岁以上组(23.2%),最低的为40~50岁组(17.9%).结论 中原地区女性HPV感染的优势亚型为HPV16,20~30岁女性HPV感染率最高.