目的 研究缺氧诱导因子-2α(HIF-2α)在子宫颈鳞癌组织中的表达情况及与肿瘤生物学特征的关系.方法 免疫组织化学染色方法检测子宫颈鳞癌组织中HIF-2α的表达.结果 40例子宫颈鳞癌组织中HIF-2α阳性表达得分为4.51±1.04,明显高于15例正常子宫颈组织的得分(2.28±1.60,P<0.001);子宫颈鳞癌患者中,有淋巴结转移的组织得分为5.00±0.89,也明显高于无淋巴结转移组织的得分(4.00±0.83,P<0.01);HIF-2α的阳性表达与子宫颈鳞癌患者的年龄无关,与子宫颈癌组织的FIGO2009分期、肿瘤大小有关.结论 HIF-2α的表达与子宫颈鳞癌的生长、侵袭有密切关系.%Objective To investigate the relationship between hypoxia inducible factor-2 alpha ( HIF-2α ) expression and tumor biological characteristics in cervical cancer tissues. Methods The expression of HIF-2α in cervical cancer tissues was detected by immunohistochemistry staining method. Results The score of HIF-2α positive expression in 40 samples of cervical cancer tissues was 4. 51 ±1. 04. Compared with the score of 2. 28 ± 1. 60 for 15 samples of normal cervical tissues, there was statistical significance between them (P<0.00l). In 40 samples of cervical cancer tissues, the score of HIF-2α positive expression in the samples with lymph node metastasis ( 5. 00 ±0. 89 ) was higher than that without lymph node metastasis ( 4. 00 ± 0. 83 , P < 0. 01 ). Although there was no relationship between the age of the patients and HIF-2α positive expression, the relationship of FIGO2009 staging and size of the tumor with HIF-2α positive expression was found. Conclusions The expression of HIF-2α correlates closely with the growth and invasion of cervical cancer.
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