miRNA应用于胰腺癌早期检测研究进展

摘要

Pancreatic cancer is a malignant tumor with poor prognosis and extremely high mortality.Its diagnosis mainly relies on clinical imaging.Current diagnostic kits for pancreatic cancer diagnosis have the disadvantages of low specificity and accuracy,which results the poor early detection and diagnosis.In recent years,molecular diagnostics has been one of newly developing clinical diagnostic means.miRNA is abnormally expressed in pancreatic cancer,and it can become a novel tumor marker.The miRNA detection technology has developed continuously.This paper aims to review the current clinical diagnosis and diagnostic markers for pancreatic cancer and explore some methods used in the early detection of miRNA for pancreatic cancer.%胰腺癌恶性度高、预后差、死亡率高，临床通常依靠影像检测，所用诊断试剂盒特异性、准确性低，使其早期发现、鉴别诊断困难。分子诊断学是近年来新发展的临床诊断手段之一。由于miRNA在胰腺癌中的特异性表达使其可以作为胰腺癌的新型诊断标志物，其相关的检测技术也因此得到不断发展。本文综述了胰腺癌当前临床诊断方法及诊断标志物，并对用于胰腺癌miRNA早期检测方法进行了探究。