血浆（1，3）-β-D-葡聚糖检测对血液病患者侵袭性真菌病的诊断价值

摘要

Objective To evaluate the detection of (1,3)-beta-D-glucosan(BDG)(G test) in hematological patients with invasive fungal disease (IFD). Methods A retrospective study was performed for 399 hematological malignancy patients,plasma G tests were performed for 2-3 times a week. The Principle and Diagnostic Criteria of the Disease of Hematopoietic System/Tumor in Patients with Invasive Fungal Infection(Revised Edition) was used as criteria. The diagnostic significance was evaluated by SPSS 11.5 software. Results The sensitivity of G test was 78.5% for the diagnosis of IFD,the specificity was 79.8%,the positive predictive value was 75.0%, and the negative predictive value was 82.7%. Conclusions Plasma BDG is correlated with IFD. Plasma G test should be taken 2-3 times per week. Combined with medical imaging,G test could improve the diagnosis of IFD and treatment efficiency and reduce the medical burden of patients.%目的：评价（1，3）-β-D-葡聚糖（BDG）检测（简称G试验）对恶性血液病患者侵袭性真菌病（IFD）的诊断价值。方法回顾性分析399例血液系统肿瘤患者每周2～3次的血浆G试验数据，以《血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则（修订版）》中的标准作为判断标准，利用SPSS 11.5统计软件分析G试验对IFD的诊断价值。结果 G试验诊断IFD的敏感性为78.5%，特异性为79.8%，阳性预测值为75.0%，阴性预测值为82.7%。结论血浆BDG水平与IFD感染有直接联系，每周检测2～3次，结合影像学判断方法能帮助诊断和排除IFD，提高IFD临床诊治效果。