目的：分析阿尔茨海默病（AD）和血管性痴呆（VD）患者血清中炎症因子和临床生化指标的变化，为临床诊断提供实验室依据。方法测定37例AD患者、36例VD患者和37例正常体检者（正常对照组）血清中炎症因子[白细胞介素-1α（IL-1α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]和生化指标｛游离脂肪酸（FFA）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A（apo A）、载脂蛋白B（apo B）、载脂蛋白E（apo E）、脂蛋白（a）[Lp（a）]、同型半胱氨酸（Hcy）｝，分析各组中各项指标的变化。结果与正常对照组比较，AD组和VD组IL-1β、IL-6、TNF-α、Hcy均明显升高（P<0.05），HDL-C、apo A均明显降低（P<0.05）；VD组LDL-C明显高于正常对照组（P<0.05），TG则明显高于AD组和正常对照组（P<0.05）。其余各项指标各组间差异均无统计学意义（P均>0.05）。结论炎症因子和生化指标的联合检测可为AD和VD的诊断提供一定的依据。%ObjectiveTo analyze the changes of serum inflammatory factors and biochemical indices in patients with Alzheimer′s disease(AD) and vascular dementia(VD),and to provide a reference for clinical diagnosis. MethodsA total of 37 AD patients,36 VD patients and 37 healthy subjects(control group) were enrolled. Serum inflammatory factors [interleukin 1 alpha(IL-1α),interleukin 1 beta(IL-1β),interleukin 6(IL-6) and tumor necrosis factor-alpha(TNF-α)] and biochemical indices such as free fatty acid(FFA),total cholesterol(TC), triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C), apolipoprotein A(apo A),apolipoprotein B(apo B),apolipoprotein E(apo E),lipoprotein(a)[Lp(a)]and homocysteine(Hcy) were determined. The changes were evaluated among the groups.Results IL-1β,IL-6,TNF-α and Hcy were increased in AD and VD groups(P<0.05),and HDL-C and apo A were decreased(P<0.05). LDL-C in VD group were increased compared with control group(P<0.05),and TG in VD group was higher than those in AD and control groups(P<0.05). The other indices had no statistical significance among AD,VD and control groups (P>0.05).ConclusionsThe determination of serum inflammatory factors and biochemical indices might be helpful for the diagnosis of AD and VD.
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