血清胱抑素检测在高龄男性血管性痴呆患者中的临床意义

摘要

Objective To detect the change in serum cystatin C (CysC) levels in very old male patients with vascular dementia (VaD) and to investigate its clinical significance. Methods A total of 45 male VaD patients with age over 75 years admitted in our department from January 2011 to December 2012 were enrolled in this study and assigned as observation group. Another 37 normal male persons at same age receiving physical examination during same period served as controls. Serum level of CysC in each patient was detected. Their skull CT scans or MR images were collected. The results were compared between the 2 groups. Results The serum level of CysC was markedly higher in the male VaD patients than in the normal controls [(1.98±0.64) vs (0.86±0.17)mg/L, P<0.01]. There was negative correlation between Mini-Mental State Examination (MMSE) score and the serum level of CysC (r=-0.592, P<0.01). Conclusion The very old male VaD patients have significantly higher serum level of CysC, which might be a marker of vessel impairment, and be one of risk factors for VaD.%目的：探讨血清胱抑素水平在高龄男性血管性痴呆（VaD）患者中的变化及临床意义。方法选取2011年1月至2012年12月在沈阳军区总医院干部诊疗科住院的＞75岁VaD男性患者45例（观察组），及同期在该科参加体检的＞75岁的正常老年人37例（对照组），收集所有研究对象的血清胱抑素标本，及头颅CT或磁共振影像。在两组间比较检测结果。结果高龄男性伴有VaD患者中血清胱抑素水平明显高于对照组[（1.98±0.64） vs （0.86±0.17）mg/L，P＜0.01]，MMSE的评分与血清胱抑素水平呈负相关（r＝-0.592，P＜0.01）。结论在高龄男性VaD患者中血清胱抑素水平升高，可能代表血管损害的严重程度，是VaD危险因素之一。