血管性痴呆患者血清炎症因子和生化指标的检测及临床意义

摘要

Objective:To explore the clinical significance of detecting serum inflammatory factors and bi-ochemical indexes in patients with vascular dementia(VD) so as to provide reference for the clinical diagnosis of patients with this disease.Methods:82 patients with vascular dementia(observation group) admitted to our hospital from October 2012 to October 2016 and 85 normal persons(control group) who underwent health ex-amination in our hospital during the same period were enrolled in this study.Serum levels of inflammatory cyto-kines and life indicators,analysis of the two groups were included in the indicators of the differences between the levels. Results:The levels of IL-1β,TNF-α and IL-6 in the observation group were[(62.69 ± 31.08) pg / mL],[(8.41 ± 2.06) foml / mL] and[(10.97 ± 5.12) pg / mL] were significantly higher in the con-trol group than those in the control group (P <0.05) The levels of Hcy, HDL-C, LDL-C, triglyceride and apolipoprotein A were [(37.51 ± 19.34) umoL / L,0.90 ± 0.23 nmoL / L,3.14 ± 1.11 nmoL / L,1.74 ± 1.02 mmoL / L, / L],there was significant difference between each index level and the control group (P <0.05). There was no significant difference in the levels of other inflammatory factors and biochemical indexes between the two groups (P> 0.05). Conclusion:There are differences in inflammatory factors and biochemi-cal indicators between vascular dementia patients and normal persons. Joint detection of inflammatory factors and biochemical indicators is helpful for clinical diagnosis of vascular dementia patients.%目的:分析探讨血管性痴呆(VD)患者血清炎症因子和生化指标检测的临床意义,以期为该病患者的临床诊断提供参考.方法:选取我院2012年10月至2016年10月收治的82例血管性痴呆患者(观察组)和同期在我院进行健康检查的85例正常者(对照组)进行研究,分别检测两组纳入者血清中炎症因子水平和生活指标变化,分析两组纳入者各指标水平之间的差异.结果:观察组患者白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)以及白细胞介素-6(IL-6)等炎症因子水平分别为[(62. 69±8.08)pg/mL]、[(8.41±2.06)foml/mL]、[(10.97±2.12)pg/mL]均分别显著高于对照组,组间差异具有统计学意义(P<0.05);另外,观察组患者同型半胱氨酸(Hcy)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)以及载脂蛋白A(apo-A)水平分别为[(37.51±19.34)μmoL/L]、[(0.90±0.23)nmoL/L]、[(3.14±1.11)nmoL/L]、[(1.74±1.02)mmoL/L]、[(1.36±0.23)nomL/L],各指标水平与对照组相比差异均具有统计学意义(P<0.05);其他炎症因子水平和生化指标两组相比无显著性差异(P>0.05).结论:血管痴呆患者炎症因子水平和生化指标等与正常人相比存在差异,通过联合检测炎症因子和生化指标有助于血管痴呆患者的临床诊断.