类风湿性关节炎患者红细胞体积分布宽度及相关炎性因子与病情活动度的相关性

摘要

目的 探讨红细胞体积分布宽度(RDW)及相关炎性因子与类风湿性关节炎(RA)病情活动度的相关性.方法 选择RA患者110例、痛风患者50例及正常对照者50名,检测其RDW、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)及抗环瓜氨酸肽(CCP)抗体等实验室指标.以疾病活动指数(DAS)28>5.1和2.6~3.2将RA组分为高活动期组(60例)和低活动期组(50例),分别比较各项指标的水平.结果 正常对照组、痛风组、RA低活动期组、RA高活动期组RDW、CRP、ESR、抗CCP抗体、RF依次升高(P<0.01).RA患者骨损伤发生率为60.9%,骨损伤组RDW、ESR和CRP明显高于无骨损伤组(P<0.01).RA患者中高滴度抗CCP抗体(>300 RU/mL)、RF(>200 IU/mL)者骨损伤发生率明显升高.结论 RDW及高滴度抗CCP抗体、RF可作为RA疾病活动程度的评价指标.%Objective To investigate the correlations of red blood cell distribution width (RDW) and related inflammation factors with disease activity in patients with rheumatoid arthritis (RA). Methods A total of 110 patients with RA,50 patients with gout and 50 healthy subjects were enrolled. RDW,erythrocyte sedimentation rate (ESR),C-reactive protein(CRP),rheumatoid factor(RF) and anti-cyclic citrullinated peptide(CCP) antibody were determined. According to disease activity score(DAS)28 levels,RA patients were classified into 2 groups,high-active group(DAS 28>5.1,60 cases) and low-active group (DAS 282.6-3.2,50 cases). Results RDW,CRP,ESR,anti-CCP antibody and RF were increased gradually in healthy control,gout,RA high-active and low-active groups (P<0.01). The rate of bone erosion in patients with RA was 60.9%. RDW,ESR and CRP in patients with bone erosion was higher than those in patients without bone erosion (P<0.01). High titers of anti-CCP antibody (>300 RU/mL) and RF (>200 IU/mL) in RA group were also related with high bone erosion rates. Conclusions RDW and high titers of anti-CCP antibody and RF can be used as parameters for evaluating disease activity of RA.