Objective To investigate clinical diagnostic value of serum cystatin C (Cys C) ,urinary microalbu-min (UmAlb) for early diabetic nephropathy (DN ) .Methods 50 cases of early diabetic patients were divided into group A (25 cases with type 1 diabetes) and group B (25 cases with type 2 diabetes) ,and 25 healthy subjects were enroll as group C .Cys C ,UmAlb and glycated hemoglobin A1c (HbA1c) were detected and the differences between groups were analyzed by ANOVA test .Then the relationship between Cys C and HbA1c were analyzed by linear re-gression and correlation analysis .Results Levels of Cys C and UmAlb in group A and B were higher than group C significantly (P<0 .05) .There was significant difference of Cys C level between group A and B (P<0 .05) .While there was no significant difference of UmAlb level between group A and B (P>0 .05) .Conclusion Determination of Cys C might be better than UmAlb in the early diagnosis of ND ,and could be positively correlated with disease pro-gression ..Appropriate detection should be selected in clinical work ,according to the characteristics of the markers and the patient′s disease condition .Furthermore ,serum Cys C monitoring could guide clinical treatment and assess disease prognosis .%目的研究血清Cys C（Cys C）、尿微量清蛋白（UmAlb）对糖尿病肾病（DN）早期患者临床诊断价值，并根据2种标志物的特点和患者的病情选择合适的检测方法。方法将75例糖尿病早期患者分为A组（25例，1型糖尿病）和B组（25例，2型糖尿病），同时选取健康对照（C组）25例。同时测定Cys C、UmAlb 、糖化血红蛋白（HbA1c），单因素方差分析各组间指标的差异，进一步通过一元线性回归讨论Cys C与 HbA1c之间的关系。结果A、B两组患者的Cys C、UmAlb水平普遍高于C组，差异有统计学意义（P＜0．05）；Cys C在A、B两组间差异有统计学意义（P＜0．05）；而UmAlb在A、B两组患者间差异无统计学意义（P＞0．05）。结论 Cys C的测定对糖尿病肾病早期诊断优于UmAlb ，且与患者病情发展呈正相关性；应根据两种标志物的特点和患者的病情选择合适的检测方法。定期检查糖尿病患者血清Cys C水平，可指导临床治疗，评估患者预后。
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