目的：比较液基细胞学检测与传统细胞学涂片检测在宫颈病变细胞学诊断中的应用效果。方法对本院2012年3月至2013年3月收治的560例疑似宫颈病变患者进行液基细胞学与传统细胞学涂片检测，以组织病理学和阴道镜检测结果为标准，比较两种方法的诊断效能。结果液基细胞学检测诊断为非典型鳞状细胞及其以上者96例，阳性检出率为17．1％。传统细胞学涂片检测诊断为巴氏ⅡB级及其以上者43例，阳性检出率为7．7％。两种方法阳性检出率比较差异有统计学意义（P＜0．05）。以组织病理学及阴道镜检测结果为标准，液基细胞学和传统细胞学涂片检测结果阳性符合率分别为为75．0％和34．9％，阳性符合率比较差异有统计学意义（ P＜0．05）。结论液基细胞学检测在宫颈病变细胞学诊断中的应用效果优于传统细胞学涂片检测，是一种准确、可靠的临床实验室诊断技术。%Objective To comparison the efficacy of liquid based cytology detection and conventional cytology smear detection in the cytological diagnosis of cervical lesions .Methods During Mar .2012 and Mar .2013 ,liquid based cytology detection and conventional cytology smear detection were performed in 560 patients with suspect diag-nosis of cervical lesions .Diagnostic efficacy of these two methods were compared ,taking histopathology and colpo-scope detection as standard methods .Results A total of 96 patients were diagnosed with lesions at least atypical squamous cells of undetermined significance by liquid based cytology detection ,and the positive detection rate was 17 .1% .A total of 43 patients were diagnosed with lesions at least grade ⅡB of Bethesda system by conventional cy-tology smear detection ,and the positive detection rate was 7 .7% .The difference of positive detection rate were with significant difference between the two methods (P<0 .05) .The positive coincidences of liquid based cytology detec-tion and conventional cytology smear detection with histopathology and colposcope detection were 75 .0% and 34 .9% ,which were with significant difference (P< 0 .05) .Conclusion Liquid based cytology detection might be more efficient than conventional cytology smear detection for the diagnosis of cervical lesions .
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