Objective To discuss the relationship between weakened ABO blood group antigens and blood matching and transfusion ,in order to develop appropriate measures for blood transfusion and appropriate counter-measures to guide rational and safe blood transfusion .Methods Clinical data of 40 patients with weakened ABO blood group antigens ,treated in the Second People′s Hospital during Jan .2010 and Dec .2012 ,were retrospectively analyzed ,including reasons causing the weakening of ABO blood group antigens .Another 40 patients with normal ex-pression level of blood group antigens were enrolled as control group ,clinical data of which were also retrospectively analyzed .Results In the 40 patients with weakened ABO blood group antigens ,28 cases were with acute non-lym-phocytic leukemia (ANLL) .Accounting for 70 .0% ,7 patients were with myelodysplastic syndrome (MDS) ,account-ing for 17 .5% ,3 patients with myelofibrosis (MF) ,accounting for 7 .5% ,and 2 patients were with chronic myeloge-nous leukemia (CML) ,accounting for 5 .0% .The post-transfusion reaction of the two groups were without statistical difference (P>0 .05) .Conclusion The weakening of blood group antigens could be usually founded in patients with ANLL and MDS .Homo type blood transfusion could effectively restore the function of antigens ,reduce the suffering of patients and promote recruitment .%目的：探讨血液病患者ABO血型抗原减弱与配血输血相关性研究，制订相应的输血对策，以便提醒临床能够予以重视，指导临床合理安全输血。方法对云南省第二人民医院2010年1月至2012年12月ABO血型抗原减弱的血液病患者40例进行病例回顾性分析。分析其抗原减弱的原因，并选择同期血型抗原正常表达患者40例为对照组，记录诊断及输血情况。同一年间血型抗原正常患者40例为对照组，比较两组患者输血后血红蛋白增加情况，并对其进行统计学处理。结果 ABO血型抗原减弱患者共计40例，其中28例急性非淋巴细胞白血病，占70．0％，7例骨髓异常增生综合征，占17．5％，3例骨髓纤维化，占7．5％，2例慢性髓性白血病，占5．0％。与对照组患者40例进行对照发现两组患者输血反应情况相似，差异无统计学意义（ P＞0．05）。结论患者的血液疾病主要集中在急慢性非淋巴细胞白血病和骨髓增生异常综合征，给每位患者输入同型血可有效恢复抗原功能，减轻患者痛苦，恢复健康。
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