黛力新联合氟西汀治疗68例老年脑卒中后抑郁患者临床分析

摘要

Objective To discuss the clinical effects and safety of combination of deanxit and floxitine in the treatment of elder patients with post stroke depression (PSD) .Methods From March 2010 to July 2013 ,68 PSD pa‐tients were collected in Yangzhou Wutaishan Hospital and divided into control group (n= 34) and observation group (n= 34) .Patients of control group were treated by floxitine ,and patients of observation group were treated by deanx‐it combined with floxitine .The scores of activity of daily living (ADL ) and Hamilton depression rating scale (HAMD) of two groups were compared before the treatment and 1 ,4 and 12 weeks after the treatment ,respectively . The clinical effects and complications of two groups were also compared .Results Before the treatment ,HAMD and ADL scores of two groups had no significant differences (P > 0 .05) .Compared with before the treatment ,HAMD and ADL scores of two groups all significantly decreased 1 ,4 and 12 weeks after the treatment (P < 0 .05) .HAMD and ADL scores of observation group were significantly lower than control group at every time point (P< 0 .05) .The effective rate of control group [73 .5% (25/34)] was significantly lower than observation group [47 .1% (16/34)] , with statistical difference (χ2 = 4 .096 ,P < 0 .05) .There was no significant difference of complication incidence be‐tween two groups (χ2 = 0 .078 ,P> 0 .05) .Conclusion Compared with fluorine treatment ,combination of deanxit and floxitine can significantly improve the depressive state of PSD elder patients and patients′self‐care abilities ,which is safe and effective ,and worthy of clinical application .%目的：探讨采用黛力新联合氟西汀治疗老年脑卒中后抑郁患者的临床疗效及安全性。方法选取2010年3月至2013年7月在扬州市五台山医院确诊并治疗的老年脑卒中后抑郁患者68例，分为对照组和观察组，每组34例。对照组采用氟西汀治疗，观察组在对照组基础上联合服用黛力新，分别在治疗前，治疗后1、4、12周对比两组患者的日常生活能力（ADL）评分和汉密尔顿抑郁量表（HAMD）评分，并对比两组患者的临床疗效及不良反应。结果两组治疗前 HAMD 评分、ADL 评分比较差异无统计学意义（P＞0．05）；与治疗前相比，治疗1、4、12周后两组患者 HAMD 、ADL 评分均明显下降，差异有统计学意义（P＜0．05）；与对照组相比，观察组 HAMD 、ADL 评分治疗后各个时间点降低更明显，差异均有统计学意义（P＜0．05）。对照组患者总有效率为47．1％（16／34），明显低于观察组的73．5％（25／34），差异有统计学意义（χ2＝4．096，P＜0．05）。两组患者不良反应发生率比较差异无统计学意义（χ2＝0．078，P＞0．05）。结论与单独采用氟西汀治疗相比，黛力新联合氟西汀用于治疗老年脑卒中后抑郁可显著改善患者的抑郁状态，同时提高了患者的生活自理能力；安全有效，值得临床推广应用。