利伐沙班对老年下肢骨折患者术后深静脉血栓形成发生率的影响

摘要

目的：探讨利伐沙班对老年下肢骨折患者术后深静脉血栓形成（DVT）发生率的影响。方法回顾性分析该院2013年9月至2014年9月收治的135例行手术治疗的老年下肢骨折患者的临床资料，按照治疗方案分为对照组（67例）和观察组（68例），分别给予常规低分子肝素钠治疗和利伐沙班治疗。观察2组的DVT发生率以及术中出血量和不良反应发生率，并进行比较。结果观察组和对照组的DVT发生率分别为2．9％和14．9％，经比较观察组显著低于对照组，P＜0．05；术后第1天、第2天观察组的引流量分别为（210．3±42．5）、（130．2±30．1）mL，显著低于对照组的（245．8±45．6）、（115．6±32．8）mL，差异有统计学意义（P＜0．05）。2组不良反应发生率比较，差异无统计学意义（P＞0．05）。结论对老年下肢骨折患者术后给予利伐沙班治疗可以更好地降低DVT发生率。%Objective To explore the influence of rivaroxaban on deep vein thrombosis(DVT) occurrence rate in elderly patients with lower limb fracture .Methods A retrospective analysis was performed on the clinical data of 135 cases of elderly lower limb fracture treated by operation in our hospital from September 2013 to September 2014 . The patients were divided into control group(67 cases) and observation group(68 cases) according to the treatment schemes .The two groups were given the routine low molecular heparin sodium therapy and the rivaroxaban therapy respectively .The occurrence rate of DVT ,intraoperative bleeding volume and occurrence rate of adverse reactions were observed and compared between the two groups .Results The occurrence rates of DVT in the observation group and the control group were 2 .9% and 14 .9% respectively ,the observation group was significantly lower than the control group with statistical difference(P<0 .05);the drainage volumes on postoperative 1 ,2 d in the observation group were (210 .3 ± 42 .5)mL and (130 .2 ± 30 .1)mL respectively ,which were significantly less than (245 .8 ± 45 .6) ,(115 .6 ± 32 .8)mL in the control group ,the differences were statistically significant(P<0 .05) .No statistical‐ly significant difference between the two groups was found in the occurrence rate of adverse reactions (P> 0 .05) . Conclusion For elderly patients with lower limb fracture ,giving rivaroxaban can better reduce the occurrence rate of DV T .