糖尿病人群中胰岛素和游离脂肪酸水平的相关性研究

摘要

Objective To investigate the correlation between insulin and free fatty acid levels in the normal population and diabetic population .Methods The patients with type 2 diabetes mellitus(T2DM ) and contemporane‐ous the healthy population undergoing the physical examination in our hospital from January 2009 to August 2014 were selected .The various biochemical indicators were observed and compared among various populations . Results In the comparison of the biochemical characteristics between the two populations ,BMI ,FPG ,2hPG ,FINS , TG ,HDL‐C ,FFA and IAI had statistically significant differences (P < 0 .05) ;In the diabetes mellitus group ,FINS was positively correlated with FFA(r= 0 .678 ,P< 0 .05) ,IAI was negatively correlated with FFA(r = - 0 .654 ,P<0 .05) .In the health group ,FINS was positively correlated with FFA(r= 0 .447 ,P< 0 .05) .Conclusion Serum FFA is elevated in the diabetic population ,insulin secretion is increased and insulin sensitivity index is decreased ,while in healthy population ,serum FFA increase is associated with the increase of insulin secretion .%目的：探讨糖尿病人群中胰岛素和游离脂肪酸水平的相关性。方法选取2009年1月至2014年8月成都市第四人民医院就诊的2型糖尿病患者及同期门诊体检的健康人群，观察比较各人群各项生化指标。结果2组人群生化特征比较，其中体质量指数、空腹血糖、餐后2 h 血糖、空腹血清胰岛素（FINS）、三酰甘油、高密度脂蛋白胆固醇、游离脂肪酸（FFA）、胰岛素敏感指数（IAI）差异有统计学意义（P ＜0．05）；糖尿病组中 FINS 与FFA 呈正相关（r ＝0．678，P＜0．05），IAI 与 FFA 呈负相关（r ＝－0．654，P＜0．05）。健康组 FINS 与 FFA 呈正相关，相关系数为0．447（P＜0．05）。结论糖尿病人群血清 FFA 升高，胰岛素分泌增加，IAI 下降，而健康人群血清FFA 升高与胰岛素分泌增加有关。