血型抗体效价在孕期检测的必要性

摘要

Objective To explore the necessity of the detection of blood group antibody titers during pregnan‐cy .Methods 98 cases of pregnant women were selected as subjects in the study ,whose blood groups were type O in prenatal testing .The blood group antibody titers of these pregnant women were tested .The blood group test ,hemol‐ysis test and bilirubin detection were processed in 98 cases of newborns as soon as birth .The relationship between blood group antibody in pregnant women and hemolytic disease of newborns (HDN) was evaluated synthetically .Re‐sults The titer of blood group antibody in pregnant women was positively correlated with the incidence of HDN of their children ( P < 0 .05) .The newborns whose parents had blood group incompatibility were divided into three groups (mother‐father‐infant blood group) :O‐A‐A group ,O‐B‐B group ,O‐AB‐A/O‐AB‐B group .The HDN inci‐dences of the three groups were 45 .5% ,34 .2% and 33 .3% respectively .And there was no significant difference a‐mong them (P> 0 .05) .Conclusion The blood group titer detection processing during pregnancy is helpful to find maternal - fetal blood group incompatibility cases and to reduce HDN incidence .%目的：探讨孕期检测孕妇血型抗体效价的必要性。方法以产前检测均为 O 型血的98例孕妇作为研究对象，予以血型抗体效价检测。对98例新生儿出生后行血型血清学检查、溶血试验及胆红素检测，对孕妇血型抗体与新生儿溶血病（HDN）发病率的关系进行综合评判。结果孕妇血型抗体滴度与 HDN 发病率呈正相关（P＜0．05）。将父母血型不合的新生儿（母‐父‐婴）分为3组：O‐A‐A 组、O‐B‐B 组、O‐AB‐A ／O‐AB‐B 组，各组 HDN发病率分别为45．5％、34．2％、33．3％，差异无统计学意义（P＞0．05）。结论孕期进行血型抗体效价的检测，可以及早发现母婴血型不合的问题，降低 HDN 发病率。