高危人群中红细胞 Duffy 抗原与 HIV 感染关系研究

摘要

目的：探讨红细胞Duffy抗原和人类免疫缺陷病毒（HIV）感染的关系。方法2008年在凉山州疾病预防控制中心和凉山州皮肤病性病防治站检测的高危人群427例，根据H IV‐1检测筛查和确诊试验结果分为试验组和对照组，两种试验结果不一致者不纳入该研究。应用血清学方法进行Duffy血型表型鉴定，比较两组Duffy血型表型分布及其与该地区已知报道的差异，以及不同Duffy血型表型的HIV感染率。结果共322例高危人群进行Duffy血型抗原鉴定，其中HIV感染156例（试验组），未感染166例（对照组），高危人群Duffy血型表型分布与同地区同民族人群比较差异无统计学意义（ P＞0．05）。322例高危人群中Fy （a＋ b－）304例（94．41％ ），其中试验组146例，对照组158例；Fy （a＋b＋）14例（4．35％ ），其中试验组6例，对照组8例；Fy （a－b＋）4例（1．24％ ），均在试验组；两组均未检出Fy（a－b－）表型；两组Duffy血型表型分布比较差异无统计学意义（P＞0．05）。Fy（a－）与Fy （a＋）高危人群，以及Fy （b＋）与Fy （b－）高危人群H IV‐1感染率比较差异均无统计学意义（ P＞0．05）。结论流行病学调查尚不能认为红细胞Duffy 抗原与 HIV感染相关，需进一步的深入研究。%Objective To investigate the relationship between erythrocyte Duffy antigen and human immunod‐eficiency virus(HIV) infection .Methods 427 cases of high‐risk group in the Liangshan Prefecture Center for Disease Control and Prevention and the Liangshan Prefecture Satation for Dermatosis and Venereal Disease Prevention and Treatment during 2008 were divided into experimental group and control group according to the results of screening and confirming test ,and cases with inconsistent results were not enrolled in this study .The serological method was a‐dopted to identify the Duffy blood group phenotype .The difference in the distribution of Duffy blood group phenotype between the two groups ,the differences of the distribution between this report and other published reports in this ar‐ea ,and HIV infection rate in different Duffy blood group phenotypes were compared .Results A total of 322 cases were carried out Duffy blood group antigen identification ,156 cases were HIV infection(experimental group)and 166 cases were non‐HIV infection(control group) .The distribution of the Duffy blood group phenotype had no statistical difference between the high‐risk population and the population of the same nationality in the same area (P>0 .05) . Among 322 high‐risk cases ,304 cases (94 .41% ) were the phenotype Fy (a+b-) ,in which the experimental group had 146 cases and the control group had 158 cases ;14 cases(4 .35% ) were the phenotype Fy(a+b+ ) ,in which the experimental group had 6 cases and the control group had 8 case;only 4 cases (1 .24% ) were phenotype Fy (a-b+ ) , which all were in the experimental group ;no case of phenotype Fy(a-b-) was detected in the two groups ;the dis‐tribution of the Duffy blood group phenotype had no statistical difference between the two groups (P> 0 .05) .The HIV infection rate in the high‐risk population had no statistical difference between the Fy (a-) and Fy(a+ ) high‐risk populations and between the Fy (b+ ) and Fy(b-) high‐risk populations(P>0 .05) .Conclusion It may not be considered from the epidemiological investigation that the erythrocyte Duffy antigen is related with the HIV infec‐tion ,which needs to conduct further deep research .