基于 Arlequin软件的 HLA 单倍型分析研究

摘要

目的：应用A rlequin软件进行 HLA单倍型的分析。方法将 HLA‐A和B两基因座位的等位基因分型数据进行格式转换，编辑成．arp格式输入文件，导入Arlequin软件进行分析计算。结果用Arlequin软件进行 HLA单倍型分析，直接得出各单倍型及等位基因的频率和统计表，分析得出19种 HLA‐A 等位基因、39种 HLA‐B等位基因和128种 A‐B单倍型。结论 A rlequin软件可用于 HLA单倍型的计算，该方法具有简便、快速、广谱、可操作性强的特点。%Objective To investigate haplotype frequencies of HLA using Arlequin software .Methods The genetic type data of alleles in human leukocyte antigen (HLA) A and B loci were transformed to the file with .arp .Then the HLA haplotypes were cal‐culated by Arlequin software .Results The frequencies of alleles and haplotypes were shown in table directly .A total of 19 HLA‐A alleles ,39 HLA‐B alleles and 128 HLA A‐B haplotypes were observed .Conclusion In conclusion ,the HLA haplotypes frequencies could be calculated by Arlequin software ,which is a simple ,convenient ,fast ,universal and operable way to analyze the haplotype .