首次根除幽门螺杆菌失败后不同补救方法的疗效分析

摘要

Objective To investigate the effect of different remedial methods after failure for first time eradica-ting helicobacter pylori.Methods 312 cases of failure for first time eradicating helicobacter pylori in our hospital were selected as the research subjects and randomly divided into the observation group and the control group,1 56 ca-ses in each group.The observation group used the improved sequential therapy,while the control group used the quadruple therapy.The treatment efficacy,helicobacter pylori eradication rate,occurrence rate of adverse reactions and patients satisfaction were compared between the two groups.The recurrence rate after treatment was also com-pared between the two groups.Results The helicobacter pylori eradication rate in the observation group was 92.31%,which was better than 73.72% in the control group,the difference was statistically significant (P <0.05);the total satisfaction degree in the observation group was 94.87%,which was better than 86.54% in the control group,the difference was statistically significant (P <0.05);the incidence of adverse reactions was 5.77% in the ob-servation group and 7.69% in the control group,there was no statistically significant difference (P >0.05 );the 1-year recurrence rate in the observation group was 4.49%,which was lower than 12.82% in the control group,the difference was statistically significant (P <0.05).Conclusion For the remedial method after failure for first eradica-ting helicobacter pylori,using the improved sequential therapy is superior to the traditional quadruple therapy,safe and effective with less adverse reactions,and worthy of further clinical research.%目的：探讨首次根除幽门螺杆菌失败后不同补救方法的疗效。方法选取首次根除幽门螺杆菌失败后的患者312例，随机分为观察组和对照组各156例，观察组应用改良序贯治疗法，对照组应用四联疗法进行治疗，比较两组患者幽门螺杆菌根除率，不良反应发生率及患者满意度，并在治疗结束后对两组复发率进行比较。结果观察组患者幽门螺杆菌根除率(92.31%)优于对照组(73.72%)，差异有统计学意义(P <0.05)；观察组的总满意度(94.87%)优于对照组(86.54%)，差异有统计学意义(P <0.05)；两组不良反应均较轻微，不影响治疗，观察组不良反应发生率为5.77%，对照组为7.69%，差异无统计学意义(P >0.05)；观察组1年复发率(4.49%)低于对照组(12.82%)，差异有统计学意义(P <0.05)。结论对于首次根除幽门螺杆菌失败后的补救方法，应用改良序贯治疗法疗效优于传统四联疗法，且安全有效，不良反应较少，值得临床进一步推广研究。