fas基因启动子区多态性与乳腺癌发病风险关系的Meta分析

摘要

目的 系统评价fas基因启动子区-1377 G/A和-670 A/G多态性与乳腺癌发病风险的相关性.方法 检索电子数据库PubMed、Embase、Web of Science、CNKI、Wanfang Data和CBM,截止日期为2017年2月10日,按纳入与排除标准筛选文献.采用Stata13.0软件进行Meta分析,评估发表偏倚并进行敏感度分析.结果 共纳入11篇研究,合并结果显示:未发现fas基因启动子区-1377 G/A和-670 A/G多态性与乳腺癌发病风险有关联;Egger′s线性回归分析显示不存在发表偏倚(P>0.05);逐个剔除研究后,发现Meta分析结果受单个研究的影响较小.结论 fas基因启动子区-1377 G/A和-670 A/G多态性可能与乳腺癌的发病风险无关.%Objective To systematically evaluate the relationship between fas gene promoter region(-1377 G/A and-670 A/G) polymorphisms and breast cancer onset risk .Methods The electronic databases of PubMed ,Embase ,Web of Science ,CNKI ,Wan-fang Data and CBM were retrieved until to expiration date February 10 ,2017 .The literatures were screened according to the inclu-sion and exclusion standard .The meta analysis was performed by using the Stata 13 .0 software .The publication bias was evaluated and sensitivity analysis was also performed .Results A total of 11 studies were included .The combined results showed that there was no association between fas gene promoter region(-1377 G/A and-670 A/G)polymorphisms and breast cancer onset risk .The Egger′s linear regression analysis revealed that no publication bias existed (P>0 .05) .After getting rid of studies one by one ,it was found that meta analysis results received little influence by single study .Conclusion fas gene promoter region(-1377 G/A and-670 A/G)polymorphisms may have no association with breast cancer onset risk .