舒血宁注射液联合多烯磷脂酰胆碱治疗酒精性肝硬化的疗效分析

摘要

目的 探讨舒血宁注射液联合多烯磷脂酰胆碱对酒精性肝硬化患者肝纤维化指标、肝功能及预后的影响.方法 选择2014年4月至2016 年5月湖北省武汉市红十字会医院收治的70例酒精性肝硬化患者,分为对照组和观察组,每组35例.对照组患者给予常规的护肝治疗和多烯磷脂酰胆碱治疗,观察组在常规治疗基础上给予舒血宁注射液联合多烯磷脂酰胆碱治疗,比较两组患者治疗前后肝纤维化指标、肝功能各项指标及预后.结果 治疗后两组患者的红细胞平均体积(MCV)、血脂及肝功能各项指标(血清总胆红素、丙氨酸氨基转移酶、γ-谷氨酰转移酶、天门冬氨酸氨基转移酶、碱性磷酸酶)水平比较,差异有统计学意义(P<0.05).与治疗后对照组相比,观察组MCV、血脂及肝功能各项指标下降幅度更明显,差异有统计学意义(P<0.05).治疗后两组患者肝纤维化指标均有所下降,差异有统计学意义(P<0.05);与治疗后对照组相比,观察组下降幅度更大,差异有统计学意义(P<0.05).结论 舒血宁注射液联合多烯磷脂酰胆碱对酒精性肝硬化患者有良好的临床治疗效果,能明显改善患者的临床症状,具有抗肝纤维化和提高肝功能的效果,临床值得推广.%Objective To investigate the effect of Shuxuening Injection combined with phosphatidylcholine on liver fibrosis indexes,liver function and prognosis in the patients with alcoholic liver cirrhosis.Methods Seventy cases of alcoholic liver cirrhosis in the Wuhan Municipal Red Cross Hospital from April 2014 to May 2016 were selected and divided into the control group(35 cases) and observation group(35 cases).The control group was given the routine liver-protecting therapy and phosphatidycholine treatment,while the observation adopted the Shuxuening Injection and phosphatidylcholine.The liver fibrosis indexes,liver function indexes and prognosis effect were compared between the two groups.Results The MCV,blood lipids and liver function indexes(serum bilirubin,ALT,GGT,AST and AKP) after treatment had statistical difference between the two groups(P<0.05).Compared with the control group after treatment,the decrease amplitudes of MCV,blood lipid and liver function indexes after treatment in the observation group were more significant with statistical difference(P<0.05).The liver fibrosis indexes after treatment in the two groups were decreased with statistical difference(P<0.05),compared with the control group after treatment,the decrease amplitude in the observation group was more larger with statistical difference(P<0.05).Conclusion Shuxuening Injection combined with phosphatidylcholine has a good curative effect in the patients with alcoholic cirrhosis,can significantly improve the clinical symptoms with anti-hepatic fibrosis and liver function improvement effects and is worthy of promotion in clinic.