SF和Lp-PLA2水平与冠心病的相关性研究

摘要

目的 探讨血清铁蛋白(SF)、血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠心病(CHD)的关系.方法 选取该院心血管内科2015年2月至2016年3月142例CHD患者为研究组,按是否含有危险因素分为不含危险因素CHD组和含危险因素CHD组.另外选取同期58例健康查体者作为健康对照组.采用电化学发光免疫法检测各组SF水平,采用双抗体夹心酶联免疫法检测各组Lp-PLA2水平.结果 与健康对照组比较,不含危险因素CHD组和含危险因素CHD组SF和Lp-PLA2水平均明显升高,差异均有统计学意义(P<0.01).通过相关分析显示,不含危险因素CHD组和含危险因素CHD组SF和Lp-PLA2均无相关性(r分别为0.055、0.067,P>0.05).通过Logistic回归分析显示,SF和Lp-PLA2与CHD独立相关(OR分别为1.898、1.921,P<0.05).不含危险因素CHD组和含危险因素CHD组SF和Lp-PLA2联合检测阳性率均高于单项检测,差异均有统计学意义(χ2分别为5.469、4.167,P<0.05).结论 SF和Lp-PLA2可作为CHD的风险因素评估指标,两者联合检测对预测CHD的发生有一定的价值.%Objective To investigate the relationships between serum ferritin (SF) and plasma lipoprotein-associated phospho-lipase A2(Lp-PLA2) with coronary heart disease(CHD) .Methods One hundred and forty-two patients with CHD in the cardiolo-gy department of our hospital from February 2015 to March 2016 were selected and divided into the risk factors group and non-risk factors group according to whether containing risk factors .Other 58 people undergoing physical examination were chosen as the healthy control group .The SF level was detected by adopting the electrochemiluminescence immunoassay method and the plasma level of Lp-PLA2 was detected by adopting the double-antibody sandwich enzyme-linked immunosorbent assay .Results Compared with the healthy control group ,the SF and Lp-PLA2 levels increased significantly in both groups with and without risk factors ,the difference was statistically significant (P<0 .01) .The correlation analysis showed that SF and Lp-PLA2 levels in the groups with-out and with risk factors had no correlation (r=0 .055 ,0 .067 ,P>0 .05) .The Logistic regression analysis showed that SF and Lp-PLA2 were independently associated with CHD (OR=1 .898 ,1 .921 ,P<0 .05) .The positive rate of combined detection of SF and Lp-PLA2 levels in the two groups with and without risk factors was significantly higher than that in the single index detection ,the difference was statistically significant (χ2 =5 .469 ,P=0 .019;χ2 =4 .167 ,P=0 .041) .Conclusion SF and Lp-PLA2 can be used as the indicators of risk assessment in CHD and their combined detection has some predictive value for predicting CHD .