The functional genomics is coming of age after the anatomy of the human genome is completed . The dramatic increase in the amount of genomic information is having a tremendous impact on biomedical research and on the way that medical treatment is processed, the major task is how to dissert the function of genes using large-scale and systematic approaches. Since genes function in the complex living creatures made of cells , the study of functional genomics will largely rely on the research of model organisms. The mouse is the closest mammalian model organism to human. Compared with other organism,mouse has many advantanges,short lifecycle,close genome size (2.5 × 109 bp in mouse vs 2.9 × 109 bp in human),available whole genome sequences and many inbred strains, easy to breed and maitain in lab. The most importantly, the genetic information of mouse gene could be modified in vivo by transgenic and gene targeting approaches.The mouse science is changing the modern biology study in general.
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