Graves病初发患者血清垂体泌乳素测定分析

摘要

目的 探讨Graves病(GD)初发患者与健康体检人群PRL水平的差异.方法 收集123例GD初发患者血清并测定其PRL水平.GD初发患者经临床表现结合甲状腺激素测定和甲状腺彩超结果确诊.收集与患者年龄和性别比例相匹配的93例健康体检人员血清并测定其PRL水平.采用SPSS 13.0统计软件进行数据的统计学处理,各计量资料以x±s表示,两样本均数的比较采用t检验,以P<0.05为差异有统计学意义,两样本率的比较采用卡方检验.结果 经卡方检验分析,GD初发女性患者中高PRL血症的比例明显高于GD初发男性患者和健康体检者.经t检验分析,不同性别和年龄段的GD初发患者与健康体检者血清PRL水平相比P<0.05,差异有统计学意义,GD初发患者体内血清PRL水平明显高于健康体检者.结论 不同性别和年龄段的GD初发患者体内血清PRL水平均明显高于健康体检者.%Objective This study was purposed to discuss whether the prolactin (PRL) concentration of the incipient Graves′ disease patients′ serum had significant difference from physical examination of healthy control subjects.Methods We collected 123 incipient hyperthyroidism patients′ serum and analyzed the PRL concentrations.The patients were diagnosed by physical examination, thyroid related hormones testing and thyroid ultrasonography.93 physical examinations of healthy peoples′ serum were collected and PRL concentrations were tested.The control subjects were matched by age and gender with the patients cohort.We analyzed the PRL concentration data from patients′ and healthy people′s serum samples.Results In both male and female patients, we found significantly higher concentrations of PRL compared to male healthy male subjects(P<0.05).Moreover, in different age stages patients, PRL concentrations were significantly higher than healthy female people(P<0.05).Conclusion Our research demonstrated that the PRL concentrations of the incipient Graves′ disease patients′ serum were significantly higher than physical examination of healthy subjects.