METHOD FOR SELECTING TACTICS OF ADMINISTRATION OF PATIENTS WITH PROLACTIN-SECRETING PITUITARY ADENOMA RESISTANT TO CONSERVATIVE TREATMENT BASED ON ANALYSIS OF INDIVIDUAL SPECIFICITIES OF CABERGOLINE PHARMACODYNAMICS

摘要

FIELD: medicine.;SUBSTANCE: using the reversed-phase high-performance liquid chromatography method with detection on a quadrupole tandem mass spectrometer with ionization in electrospray in the positive ion scan mode, after taking the drug at a dose of 0.5 mg, the cabergoline concentration in the patient's blood plasma is determined. With an increase in drug concentration after taking in 240 minutes, the need to continue conservative cabergoline therapy is identified. In the absence of cabergoline concentration growth dynamics in blood, alternative methods of treatment are used.;EFFECT: invention allows to form a personalized approach to the treatment of patients with partially resistant prolactin-secreting adenomas of the pituitary gland, to identify candidate patients as soon as possible to perform operative treatment, to avoid the development of complications due to ineffective therapy.;2 dwg, 2 ex