凝血指标、免疫因子和妊娠高血压综合征病情的关系观察

摘要

Objective To study the relationships among blood coagulation condition index,immune inflammatory factor and pregnancy-induced hypertension syndrome.Methods From January 2015 to October 2016,we recruited patients of pregnant women,150 cases of pregnancy-induced hypertension syndrome,in which 50 cases of mild preeclampsia,50 cases of severe preeclampsia and eclampsia 50 cases;In addition,we also recuited 30 cases of healthy pregnant women,30 patients with normal late pregnancy as control groups.Immune turbid metric method is used to detect the immune indexes,plasma coagulation indexes,including C3 and C4,IgA,IgG,IgM,D-D levels,part thrombin time PT,activated clotting time APTT,Fib fibrinogen live enzymes.Results ①Among the healthy non pregnant control group,normal late pregnancy group and mild preeclampsia C3 and C4,IgA,IgG,IgM has no obvious difference,P ＞ 0.05.Compared to healthy non pregnant control group,normal late pregnancy group,,severe preeclampsia group showed significant lower level of C3,IgG,IgM,also eclampsia C3 and C4,IgA,IgG,IgM significantly lower,P ＜0.05.②Compared to healthy non pregnant group,normal late pregnancy and gestational hypertension groups showed significant lower levels of PT and APTT,and their Fib and D-D levels were significantly higher,P ＜0.05.Compared with control group,normal late pregnancy,gestational hypertension groups has significantly smaller PT and APTT value,Fib and D-D levels significantly higher,P ＜ 0.05.Gestational hypertension group comparison,control and mild preeclampsia,severe preeclampsia and eclampsia showed significantly smaller PT and APTT values,Fib and D-D levels significantly higher,P ＜ 0.05.Contrast and severe preeclampsia,eclampsia,showed significantly smaller PT and APTT,significantly higher Fib and D-D levels,P ＜ 0.05.Conclusion The blood coagulation indexes,immune inflammatory factor and pregnancyinduced hypertension syndrome are highly correlated in patients with pregnancy-induced hypertension syndrome.C3,C4 IgA,IgG,IgM,D-D level,and blood clotting index,are conducive for early detection and monitoring of the patient's illness development.%目的 探讨凝血指标、免疫炎症因子和妊娠高血压综合征病情的关系.方法 收集2015年1月至2016年10月在本院就诊的妊娠高血压综合征孕妇150例,其中轻中度子痫前期50例,重度子痫前期50例,子痫50例;另外选取30例健康非孕妇女和30例正常晚期妊娠妇女作为对照,采用免疫比浊法检测各组受检者的免疫指标、血浆凝血指标,包括C3、C4、IgA、IgG、IgM、D-D水平、凝血酶时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib).结果 ①健康非孕对照组、正常晚期妊娠组、轻中度子痫前期组三组C3、C4、IgA、IgG、IgM无明显差异,P＞0.05.和健康非孕对照组、正常晚期妊娠组对比,重度子痫前期C3、IgG、IgM显著减低,子痫组C3、C4、IgA、IgG、IgM更低,P＜0.05.②和健康非孕组对比,正常妊娠晚期组和妊娠高血压各组PT和APTT值显著减小,Fib和D-D水平显著增高,差异具有统计学意义(P＜0.05).和正常晚期妊娠组对比,妊娠高血压各组PT和APTT值显著减小,Fib和D-D水平显著增高,差异具有统计学意义(P＜0.05).妊娠高血压各组内对比,和轻中度子痫前期对比,重度子痫前期组、子痫组PT和APTT值显著减小,Fib和D-D水平显著增高,差异具有统计学意义,P＜0.05.和重度子痫前期组对比,子痫组PT和APTT值显著减小,Fib和D-D水平显著增高,差异具有统计学意义,P＜0.05.结论 凝血指标、免疫炎症因子和妊娠高血压综合征病情的关系密切,对妊娠高血压综合征患者进行C3、C4、IgA、IgG、IgM、D-D水平、凝血指标的检测,有利于尽早发现和监测患者的病情发展情况.