目的:分析不同亚型多囊卵巢综合征(PCOS)不孕患者在体外受精-胚胎移植(IVF-ET)治疗周期中,采用低剂量递增促排卵方案的临床治疗效果.方法:回顾性分析2006年5月至2010年4月按低剂量递增促排卵方案行IVF-ET治疗PCOS不孕患者共264周期,对患者按2003年鹿特丹标准分为3个亚型,Ⅰ型组86周期,Ⅱ型组157周期,Ⅲ型组21周期,比较各型实验室及临床相关指标的差异.结果:Ⅱ型组注射HCG日>14 mm卵泡数(10.9±5.8)、可利用胚胎率(65.9%)低于Ⅰ型组(15.9±7.3;73.4%)和Ⅲ型组(14.0±7.2;77.4%),差异有统计学意义(F=17.351,P<0.001;χ2=19.471,P<0.001);余临床及实验室结果以及妊娠结局差异无统计学意义.结论:低剂量递增促排卵方案是PCOS不孕患者有效的促排卵方案之一,不同亚型的PCOS患者临床结局相似.%Aim :To compare clinical results of low-dose increasing ovarian stimulation in IVF patients with different sub -type of polycystic ovary syndrome ( PCOS). Methods: The patients with PCOS (264 IVF-ET cycles ) received low-dose increasing ovarian stimulation treatment in our center from May 2006 to April 2010 were retrospectively analyzed. Patients were divided into 3 subtypes according to Rotterdam Standard 2003. There were 86 cycles in type I group, 157 cycles in type II group,and 21 cycles in type III group. The laboratorial and clinical indicators in each subgroup were compared respectively . ReSUltS;The number of follicles > 14 mm of subgroup Ⅱ(10. 9 ±5. 8) at HCG day, and the rate of acquired embryos in subgroup Ⅱ(65. 9%)was lower than those in subgroup Ⅰ(15.9 ±7.3;73.4%) and subgroup Ⅲ(14.0 ±7.2;77.4%) ,and the differences were significant (F = 17. 351 ,P < 0. 001; χ2 =19. 471, P < 0. 001). The other clinical results and experiment re -suits had no significant difference. Conclusion:Low-dose increasing ovarian stimulation can be used as an effective protocol in infertility patients with PCOS, and the clinical results are similar to patients with different subtypes of PCOS .
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