非酒精性脂肪肝患者肝组织中 Irisin 的表达

摘要

Aim: To evaluate the expression of Irisin in liver tissue of patients with nonalcoholic fatty liver disease (NAFLD) and analyze its significance.Methods: The clinical data of patients ,including 56 cases of biopsy-proven nonal-coholic simple fatty liver(NAFL)and 75 cases of nonalcoholic steatohepatitis (NASH) were retrospectively analyzed.Twen-ty cases without fatty change or adipose hepatitis were the control .Irisin expression in liver biopsy tissue was detected by immunohistochemical SP method.Results: There were no significant differences in age or sex ratio among the 3 groups (P >0.05).Compared with control,there was abnormal lipid metabolism in NAFL and NASH groups .The Irisin expression level in NAFL and NASH groups was higher compared with control group (P <0.05),while there was no significant differ-ence between NAFL and NASH groups (P >0.05).Conclusion: Irisin may act as a compensatory regulation factor for lip -id accumulation in hepatocytes .%目的：探讨 Irisin 在非酒精性脂肪肝（NAFLD）患者肝穿刺组织中的表达及其意义。方法：回顾性分析病理活检确诊的非酒精性单纯性脂肪肝（NAFL，n ＝56）、非酒精性脂肪性肝炎（NASH，n ＝75）患者及无脂肪变和脂肪性肝炎的正常者（n ＝20）的临床资料，免疫组化 SP 法检测各组肝穿刺组织中 Irisin 的表达水平。结果：3组年龄及性别构成比差异无统计学意义（P ＞0．05）。与正常对照组相比，NAFL 组及 NASH 组存在脂质代谢异常。 NAFL 组和 NASH 组肝组织中 Irisin 表达水平高于对照组（P ＜0．05），但 NAFL 组和 NASH 组间差异无统计学意义（P ＞0．05）。结论：Irisin 可能是一种补偿性调节肝脏脂质蓄积的因子。