基于DN A链置换和亚分子瓦的可控4臂DN A分子瓦自组装

摘要

A controllable 4-arm DNA tile self-assembly based on DNA sub-tile and DNA strand displace-ment (DSD)was proposed based on original sub-tile.The impacts on time responses of this design was studied by designating new reaction rates to toeholds.Visual DSD results showed that increasing the popula-tion ratio-active strands to arm strands and assigning higher reaction rates of toeholds could accelerate DNA tile self-assembly.These simulation results could convince the possibility of implementing controllable DNA tile self-assembly at room temperature in laboratory.%提出了用DNA链置换电路控制亚分子瓦（sub-tile）自组装4臂DNA分子瓦的模型，在亚分子瓦原型基础上设计了亚分子瓦的分解结构，通过修改链置换反应中“小支点”的反应速率，观察“小支点”反应速率对这种可控的DNA自组装时间响应的影响．Visual DSD仿真结果表明，通过提高控制链与其他反应链的比值及“小支点”的反应速率，可以加快DNA亚分子瓦自组装的反应速度，同时也证实了在室温下实现可控的DNA亚分子瓦自组装的可能性．