新型手性共聚物修饰电极及其在手性识别中的应用

摘要

A novel type of chiral copolymer modified glassy carbon electrode was prepared via electro-copolymerization method. The effect of molecular structure and feed ratios of monomers on the chiral recognition of electrodes were investigated. And the synthesis of chiral monomers (S)-l, l'-binaphthyl-2, 2'-diyl bis ( N-( 6-hexanoic acid-1-yl) pyrrole) ( BPL) and (S)-l, l'-binaphthyl-2,2'-diyl bis (4-( lH-pyrrol-1-yl) benzoate) (BAD was also reported. The as- ' prepared copolymers were characterized by SEM, UV-Vis and CD spectra. The chiral recognition of the copolymer modified electrodes was analyzed by cyclic voltammetry. The results showed that both electrodes possess chiral recognition. Besides, the chiral recognition of electrodes could be enhanced by increasing the ratio of chiral units or by replacing the alkyl chain with more rigid benzene ring.%实验采用电化学共聚法制备了一类新型手性共聚物修饰玻碳电极,初步分析了聚合单体分子结构以及共聚单体投料比对电极手性识别性能的影响,报道了手性聚合单体(S)-1,1’-联萘基-2,2’-双(N-取代吡咯己酸酯)(BPL)和(S)-1,1'-联萘基-2,2'-双(N-取代吡咯苯甲酸酯)(BAL)的合成方法；采用了扫描电子显微镜、紫外-可见光谱和圆二色谱等分析方法对共聚物进行了表征,运用循环伏安法测试了共聚物修饰电极的手性识别性能.实验表明:两种共聚物修饰电极均具有明显的手性识别性能,通过增加共聚物结构中手性单元比例或者采用刚性结构苯环替代BPL单体分子中的长链烷烃可以提高共聚物修饰玻碳电极的手性识别能力.