乙型肝炎病毒对精子和辅助生殖技术结局的影响

摘要

乙型肝炎病毒(HBV)垂直传播近年来受到广泛关注,随着辅助生殖技术(ART)的迅猛发展,越来越多的HBV携带夫妇借助于ART获得了子代.然而,HBV的垂直传播现象仍然不可完全避免,尤其是父婴垂直传播.原因在于HBV感染精子的机制至今仍未阐明.了解HBV携带者精子的HBV感染状况及其与精子参数的关系,随访男性HBV患者接受ART治疗后的结局,揭示HBV感染精子的机制,将有助于在解决了生育问题的同时更好地为防控HBV的父婴垂直传播提供新的思路.%With the development of assisted reproductive technology (ART), more and more hepatitis B virus ( HBV ) -infected couples have their own children successfully; however, vertical transmission of HBV in ART, especially father-to-child transmission, cannot be avoided. The mechanism of attachment and penetration of HBV into human sperm is still not known. Therefore, understanding the state and mechanism of HBV infection of sperm and the impact of HBV on sperm parameters, following up the ART outcome in man with HBV infection are helpful to solve the fertility problem and to control father-to-child vertical HBV infection.