壮药扁担藤醇提取物对 CCl4所致小鼠肝损伤的保护作用

摘要

Objective This article aims to study the protective effects of alcohol extract from Tetrastigma planicaule (Hook.f.)Gagnep on a mould cute liver injury caused by CCl4 in mice. Methods Mouse acute liver injury model was established by intraperitoneal injection 0.15% CCl4 in mice.The effects of alcohol ex-tract from Tetrastigma planicaule (Hook.f.)Gagnep on serum aspartate transaminase (AST)activity,on al-anine transaminase (ALT)activity,on superoxide dismutase (SOD)activity and Malondialdehyde (MDA) content in liver homogenate,and on the liver indexes were tested.A pathological examination for the mice liver tissues was performed. Results The alcohol extract of Tetrastigma planicaule could significantly resist the increase of ALT and AST in mice with acute liver injury caused by CCl4 ,and dowregulated MDA content of liver homogenate,and improved SOD activity.The pathological section showed the extract could improve the pathological changes of liver tissues. Conclusion The alcohol extract of Tetrastigma planicaule has remark-bale protective effect against liver injury.%目的：研究扁担藤醇提物抗 CCl4所致小鼠急性肝损伤效果。方法采用0.15% CCl4对小鼠腹腔注射，建立小鼠急性肝损伤模型，检测扁担藤醇提取物对血清丙氨酸转氨酶(ALT)活性、天冬氨酸转氨酶(AST)活性、肝匀浆超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量、肝指数的影响，并对肝组织进行病理学检查。结果扁担藤醇提物能显著降低 CCl4所致肝损伤小鼠的血清 ALT、AST 值升高并降低肝匀浆中 MDA 的含量，增强 SOD 的活性。病理学切片显示对肝组织的病理变化有显著的改善。结论扁担藤醇提物具有显著地抗肝损伤的作用。