The Possible Role of Catecholamines in the Protective Effect of General Anesthetics Against Kidney Lesions in Rats Subjected to Hemorrhagic Hypotension

摘要

Dibenamine, 15 mg/kg, injected in rats anesthetized with ketamine, 60 min before bleeding for 60 min aginst 40 mm Hg, significantly reduced the severity of kidney lesions. The maximum bleeding volume was reduced by 14%. Adrenalectomy also reduced the bleeding volume but all animals died within 24 hr. In unanesthetized rats bled against 40 mm Hg, plasma adrenaline and nor-adrenaline rose approximately tenfold as compared with unbled animals. It is concluded that vasoconstriction due to the release of catecholamines is an important factor in the generation of kidney lesions during hypotension in rats and that the protective effect of a number of general anesthetics largely depends on their ability to suppress the release of catecholamines.