血清KL-6水平在诊断间质性肺疾病中的作用及其敏感性与特异性分析

摘要

Objective To investigate the role of serum KL-6 in the diagnosis of interstitial lung disease(ILD)and its sensitivity and specificity.Methods A total of 126 ILD patients who were treated in Hami Central Hospital were enrolled as study group.Meanwhile,126 patients with the other lung diseases was selected as the other lung disease group and 126 healthy subjects was selected as healthy group(n=126).The levels of serum KL-6 of all subjects were detected by chemiluminescence immunoassay.Results The study group showed a remarkably higher serum concentration of KL-6 than the other disease group and the healthy group(P<0.05 ).The positive rate of KL-6 in the study group(85.71%)was significantly higher than that of the other disease group and the healthy group(P<0.05).The sensitivity and specificity of serum KL-6 for ILD diagnosis was 94.73% and 70.00%,respectively.There was significant difference as to serum KL-6 levels among patients with cryptogenic organizing pneumonia(COP),idiopathic pulmonary fibrosis(IPF),connective tissue disease-associated pulmonary disease(CTD-ILD),and alveolar proteinosis(PAP)in the study group(P<0.05).Conclusions Serum KL-6 has a high sensitivity and specificity in the diagnosis of ILD.It has high clinical diagnostic value.%目的 探究血清涎液化糖链抗原-6(KL-6)水平在诊断间质性肺疾病(ILD)中的作用及其敏感性与特异性.方法 选取哈密市中心医院收治的126例ILD患者作为研究组,并选择其他肺疾病组(n=126)和健康组(n=126),采用化学发光免疫测定法分别检测各组血清KL-6水平.结果 研究组的血清KL-6浓度明显高于其他疾病组和健康组(P<0.05);研究组的KL-6阳性检出率明显高于其他疾病组和健康组(P<0.05),阳性率可达85.71%.血清KL-6诊断ILD的敏感度为94.73%,特异度为70.00%.研究组中隐源性机化性肺炎(COP)、特发性肺纤维化(IPF)、结缔组织病相关间质性肺疾病(CTD-ILD)以及肺泡蛋白沉着症(PAP)的血清KL-6平均浓度之间存在较大差异(P<0.05).结论 血清KL-6水平在诊断ILD时,其敏感性和特异性均高,具有较高的临床诊断价值.