帕罗西汀对氯胺酮镇痛效应的影响

摘要

Objective To observe the effect of paroxetine on analgesic effect of ketamine . Methods 40 mice were randomly divided into 4 groups (n=10 each) ; NS group, ketamine (K) group, paroxetine (P) group, paroxetine plus ketamine (P + K) group. The tail-flick latency of each group before and after drug administration was determined by tail-flick test. Results Compared with NS group , the tail-flick latency of K group had extended from 10 min to 40 min (P<0.05 or P<0.01) after the drugs were administered. The tail-flick latency of K group was longer than P + K group from 10 min to 40 min after the drugs were administered (P <0.05 or P <0.01) . Conclusion Paroxetine can antagonize the analgesic effect of ketamine .%目的 观察帕罗西汀对氯胺酮镇痛效应的影响.方法 将40只昆明种小鼠随机分为4组(每组n=10):生理盐水(NS)组﹑氯胺酮(K)组﹑帕罗西汀(P)组﹑帕罗西汀+氯胺酮(P+K)组.利用甩尾实验测定各组小鼠用药前后的甩尾潜伏期(tail-flick latency,TFL).结果 与NS组相比,给药后10～40 min K组小鼠TFL提高(P<0.05或P<0.01).与P+K组相比,给药后10～40min K组小鼠TFL较长(P<0.05或P<0.01).结论 帕罗西汀能够拮抗氯胺酮的镇痛作用.