Objective To investigate the clinical effect of video assisted thoracoscopic surgery(VATS) in treatment of thoracic tumor. Methods Fifty-two patients with thoracic tumor were divided into two groups, twenty-six patients in control group were treated with traditional thoracotomy, while the twenty-six patients in observation group were treated with VATS. The peroperative situations, the level of laboratory parameters and postoperative follow-up were observed and compared between the two groups. Results Compared with control group, the size of operative incision was small(P <0.05), the amount of bleeding in operation, the postoperative drainage and the dosage of postoperative analgesics were less(P<0.05), and the hospitalization time was shorter in obervation group(P <0. 05). Before operation, there was no significant difference in the levels of serum C-reactive protein(CRP), interleukin-6(IL-6), IL-8 and tumor necrosis factor-a (TNF-α) between the two groups(P <0. 05). The levels of serum CRP, IL-6, IL-8 and TNF-α at the time of 24 and 72 hours after operation were significantly higher than those before operation in the two groups(P < 0. 05). The levels of serum CRP, IL-6, IL-8 and TNF-α at the time of 72 hours after operation were significantly lower than those at the time of 24 hours after operation in the two groups (P < 0. 05). At the time of 24 and 72 hours after operation, the levels of serum CRP, IL-6, IL-8 and TNF-α in observation group were significantly lower than those in control group(P < 0. 05). The incidence of postoperative complications and 3-year recurrence rate in observation group were significantly lower than those in control group(P <0. 05). The 3-year survival rate in observation group was significantly higher than that in control group (P < 0. 05). Conclusion VATS for the treatment of thoracic tumor can reduce surgical trauma, shorten hospitalization time, reduce the incidence of postoperative complications, and improve survival rate of patients.%目的 探讨电视胸腔镜手术(VATS)治疗胸部肿瘤的临床效果.方法 52例胸部肿瘤患者分成2组,对照组26例给予传统开胸术治疗,观察组26例给予VATS治疗；观察比较2组患者的围术期情况、实验室指标水平和术后随访情况.结果 与对照组比较,观察组患者的手术切口小(P＜0.05),术中出血量、术后引流量和术后镇痛药使用量少(P＜0.05),住院时间短(P＜0.05).术前2组患者血清C反应蛋白(CRP)、白细胞介素(IL)-6、IL-8和肿瘤坏死因子(TNF)-α水平比较差异均无统计学意义(P＞0.05)；术后24、72 h,2组患者血清CRP、IL-6、IL-8和TNF-α水平均显著高于术前(P＜0.05)；2组患者术后72 h血清CRP、IL-6、IL-8和TNF-α水平均显著低于术后24h(P＜0.05)；术后24、72 h,观察组患者血清CRP、IL-6、IL-8和TNF-α水平均显著低于对照组(P＜0.05).观察组患者术后并发症发生率和3 a复发率均显著低于对照组(P＜0.05),观察组患者3 a存活率显著高于对照组(P＜0.05).结论 VATS治疗胸部肿瘤可减轻手术创伤,缩短住院时间,降低患者术后并发症发生率,提高患者存活率.
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