单纯化疗治疗尤文肉瘤术后脑、肺转移的临床效果分析

摘要

Objective The treatment for multiple metastases of Ewing sarcoma is rarely reported .The pa-per is to study the curative effect of chemotherapy for multiple metastases of lung and brain after surgery in a case of Ewing sarcoma .Method A 25-year-old male was admitted to hospital in January 2013 ,and the clinical data were analysed .In April 2011 ,he was diagnosed with Ewing sarcoma of the left proximal fe-mur .The treatment consisted of enbolc resetion with femoral prosthesis replacement ,completed by chem-otherapy (VAC+IE regimen) before surgery .However ,chemotherapy was not performed as required af-ter surgery ,multiple metastases of lung and brain occurred two years later .Chemotherapy (VAC+IE reg-imen) was performed again .Results The symptom of headache was observably relieved after chemothera-py .Chest X-ray before and after the chemotherapy showed the space-occupying lesions disappeared .Head CT scan before and after the chemotherapy showed shrinkage of metastases with symmetrical ventricle . Conclusion VAC+ IE as chemotherapy regimen of Ewing sarcoma is an effective treatment for multiple metastases of lung and brain .%目的：探讨单纯化疗对尤文肉瘤术后脑、肺多发转移的治疗效果。方法回顾分析2013年1月收治的1例尤文肉瘤术后患者的临床资料。男性，25岁。2011年4月于我院确诊为左股骨上段尤文肉瘤，按VAC＋IE方案化疗1个疗程后，行瘤段切除，肿瘤假体置换。术后病人未按医嘱要求进行化疗，2a后出现脑、肺转移。再次按照VAC＋IE方案化疗。结果再次化疗1个疗程后，病人头痛症状明显缓解。肺部X线片示治疗后肺野内占位消失。头颅CT平扫示化疗后脑实质转移灶较化疗前显著缩小，脑室系统对称。结论 VAC＋ IE化疗方案对尤文肉瘤脑、肺多发转移的治疗有效。