EGFR异常表达与胸腺上皮性肿瘤组织学分型关系研究

摘要

Objective To evaluate the expression and differential significance of EGFR in thymic epithelial tumors (TETs)with the aim to provide useful information for tumor biology and prospective therapy. Methods In this study,we analyzed the expression of EGFR in 60 cases of thymic epithelial tumors.The tumors included 52 thymomas and 8 thymic carcinomas which were categorized according to the current WHO classification systems.Results 46 cases (76.7%)of thymus epithelium tumor showed positive ex-pression of EGFR.Which significantly higher than that in normal thymus tissue (1/11,9.1%)(P<0.05). There was statistic difference between histological subtypes (P<0.05).The positive ratio of thymic carci-noma (100%,8/8)and type B3 (90.9%,10/11)was higher than other type.All cases of type A and meta-plasia were negative.There were no significant difference of EGFR among different clinical stages (P>0.05).Con-clusion Overexpression of EGFR correlated with generation and biological behavior of thymus epithelium tumor.The positive ratio of EGFR in thymus epithelium tumor was significantly higher than that in normal thymus tissue.The positive ratio of EGFR in type B3 was similar to thymus carcinoma,relatively higher than that in other types.%目的：探讨表皮生长因子受体（EGFR）的异常表达与胸腺上皮性肿瘤组织学分型、临床分期的关系。方法应用免疫组织化学方法（EnVision二步法）检测60例胸腺上皮性肿瘤（A型2例，AB型19例，B1型4例， B2型14例，B3型11例，化生性胸腺瘤2例，胸腺癌8例）和11例正常胸腺组织中EGFR的异常表达。结果60例胸腺上皮性肿瘤中46例（76．7％）存在 EGFR 阳性表达，显著高于其在胸腺正常组织中的阳性表达（1/11，9．1％）（P ＜0．05）。EGFR阳性表达在各亚型胸腺上皮性肿瘤间差异有统计学意义，其中胸腺癌阳性率最高（100．0％），B3型次之（90．9％），A型和化生性胸腺瘤均为阴性。EGFR阳性表达在胸腺上皮性肿瘤不同临床分期的表达差异无统计学意义（P ＞0．05）。结论生物靶向治疗相关基因 EGFR的异常表达与胸腺上皮性肿瘤的发生、发展及生物学行为相关，EGFR在B3型胸腺瘤中的阳性率与其在胸腺癌中的阳性率相似，相对高于其他亚型。