目的 探讨河南省农村地区人群不同类型肥胖的家庭聚集性.方法 资料来源于代谢综合征的发病趋势和综合控制研究的河南现场调查,家庭聚集性分析应用二项分布拟合优度卡方检验,以及患者与非患者一级亲属间患病率的比较；遗传度的计算采用George和Elston的回归模型；利用偏相关分析不同人体测量学指标一级亲属间的相关性.结果 全身性肥胖和中心性肥胖家庭患病数不符合二项分布,且不同类型肥胖患者一级亲属的患病率均明显高于非患者一级亲属患病率,体重指数、腰围和腰身比的遗传度分别为(44±6)％、(48±6)％和(46±6)％.亲子、同胞和夫妻间各肥胖测量指标均具有相关性.结论 河南省某农村地区成年人群全身性肥胖和中心性肥胖的患病均呈现家庭聚集性.%Objective To study the family aggregation of different types of obesity among the population in a rural area of Henan Province. Methods The data came from the field study of incidence and comprehensive control of metabolism syndrome in Henan rural areas. Chi-square test for goodness of fit to binomial distribution was used to analyze the family aggregation and compare the prevalence of obesity patients and non-obesity first-degree relatives. George and Elston regression model was used to estimate the heritability. Partial correlation analysis was used to analyze the correlation of the anthropometric indices among the first-degree relatives. Results According to the Chi-square test for goodness of fit to binomial distribution, the distribution of patients in general obesity families and central obesity families did not confirm to the binomial distribution, and the prevalence of first-degree relatives of patients with different types of obesity was significantly higher than that of first-degree relatives of non-obese patients. The heritability of body mass index, waist circumference and waist-height ratio was (44 ± 6)%, (48 ±6)% and (46±6)%, respectively. The indexes of obesity among parents and children, siblings and couples were correlated. Conclusion The prevalence of general obesity and central obesity has the characteristic of family aggregation among the adult population in that rural area of Henan Province.
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