C-Met 蛋白与 HGF 蛋白在舌鳞癌细胞中的表达及临床意义

摘要

目的：探讨 C-Met 蛋白与肝细胞生长因子(HGF)蛋白在舌鳞癌细胞中的表达及临床意义。方法选取2011年6月至2013年5月我院口腔科收治的舌鳞癌患者46例作为实验组，另取同期在我院进行良性肿瘤切除患者27例作为对照组，正常组织为正常组，均进行免疫组化测定 C-Met 蛋白及 HGF 蛋白的表达。结果实验组中 C-Met 的阴性表达率为21.7%(10/46)，弱阳性表达率为26.1%(12/46)，强阳性表达率52.2%(24/46)；对照组的阴性表达率为77.8%(21/27)，弱阳性表达率为15.8%(5/27)，强阳性表达率为3.7%(1/27)，两组比较差异具有统计学意义(P <0.001)。实验组中 HGF 蛋白的阴性表达率为17.4%(8/46)，弱阳性表达率为58.7%(27/46)，强阳性表达率23.9%(11/46)；对照组阴性表达率为63.0%(17/27)，弱阳性表达率为37.0%(10/27)，强阳性表达率为0.0%(0/27)，两组比较差异具有统计学意义(P <0.001)。C-Met 蛋白的表达与淋巴结转移比较，差异具有统计学意义(P <0.05)；HGF蛋白的表达与病理分级、淋巴结转移等比较，差异具有统计学意义(P <0.05)。结论C-Met 蛋白及 HGF 蛋白在舌鳞癌细胞中有显著性表达，且与舌鳞癌的发生、发展有密切关系。%ABSTRACT:Objective To study the expressions of C-Met and hepatocyte growth factor (HGF)in tongue squamous cell carcinoma and their clinical significance.Methods We analyzed 46 patients (the treatment group) with tongue squamous carcinoma and 27 patients (the control group)with benign tumor treated in our hospital between June 201 1 and May 2013.The expressions of C-Met and HGF were detected by immunohistochemistry. Results In the experimental group,C-Met negative expression rate was 21.7% (10/46),weak positive expression rate was 26.1% (12/46),and strong positive expression rate was 52.2% (24/46).The above expression rates were 77.8% (21/27),1 5.8% (5/27),and 3.7% (1/27)in the control group.The two groups differed significantly (P <0.001).In the experiment group,the negative expression of HGF protein was 1 7.4% (8/46 ),weak positive expression rate was 58.7% (27/46),and strong positive expression rate was 23.9% (1 1/46).The above expression rates in the control group was 63.0% (1 7/27 ),37.0% (10/27 ),and 0.0% (0/27 ).The two groups differed significantly (P <0.001).The expression of C-Met protein was significantly related to lymph node metastasis (P <0.05).The expression of HGF protein was significantly related to pathological grading and lymph node metastasis (P <0.05).Conclusion The expressions of C-Met and HGF in tongue squamous cell carcinoma are significantly higher.And the occurrence and development of tongue squamous cell carcinoma are closely related to the expressions of C-Met and HGF.