早期应用透明质酸钠尿道灌注对前列腺术后尿道狭窄的预防

摘要

Objective To explore the experience of early transurethral use of sodium hyaluronate in the pre-vention of urethral stricture after transurethral prostatectomy (TURP). Methods The total of 1460 patients who had underwent TURP were divided into 2 groups:sodium hyaluronate was injected transurethrally after removal of catheters in the experimental group,while catheters were routinely removed as the control. Results No ure-thral stricture occurred in the first month after TURP in all the patients. In the experimental group 16 patients (1. 67%)had urethral stricture in the 2~15 months after TURP,who recovered well after urethral dilation and transurethral use of sodium hyaluronate. In the control group 22 patients (4. 40%)had urethral stricture in the 1~15 months after TURP,who recovered well after urethral dilation but 7 patients had recurrent urethral stric-ture. Conclusions Urethral stricture is the common complication after TURP and the early transurethral use of sodium hyaluronate can effectively reduce the occur of this complication,which is worthy of application.%目的：探讨早期应用透明质酸钠尿道灌注对经尿道前列腺电切（transurethral prostatecto-my，TURP）术后尿道狭窄的预防经验。方法1460例经尿道前列腺电切术患者分为试验组960例和对照组500例，试验组患者术后拔除导尿管后行透明质酸钠尿道内灌注、对已经发生尿道狭窄的患者先行尿道扩张然后再灌注透明质酸钠，对照组术后常规拔除导尿管。结果1460例患者术后1个月内均未发生尿道狭窄，排尿通畅。试验组16例患者术后2～15个月发生尿道狭窄，占1．67％，均行单纯尿道扩张并注入透明质酸钠治愈，随访6～15个月，排尿通畅。对照组22例患者术后1～15个月发生尿道狭窄，占4．40％，单纯行尿道扩张治愈，随访6～15个月，其中7例再次发生尿道狭窄。结论尿道狭窄为TURP术后常见并发症，早期尿道内灌注透明质酸钠及尿道扩张后注入透明质酸钠对预防和降低尿道狭窄的发生具有良好的作用，值得推广应用。