含色氨酸过渡金属离子受体的合成与识别

摘要

以氨羧配体EDTA作为二价模板框架,设计合成以色氨酸为核心、含酪氨酸的开链式结构的生物受体分子EWY,利用圆二色光谱(CD)、荧光光谱和电喷雾质谱(ESI-MS)等分析手段研究其与碱土金属离子(Ca2+,Ba2+,Mg2+)和过渡金属离子(Cu2+,Fe2+,Co2+,Ni2+,Mn2+)以及碱金属离子(Li+,Na+,K+)之间的相互作用.结果表明,在水溶液中金属离子与吲哚环之间存在相互作用,该受体对过渡金属离子有着良好的选择性识别能力.%This work is to investigate the interaction between metal ions ( Ca2+, Ba2+ , Mg2+ , Gu2+, Fe2+ , Go2+ , Ni2+, Mn2+ , Li+ ,Na+ and K+ ) and the receptor ( EWY ), which is prepared by using available multidentato amino-carbexylate, EDTA, respectively, as divalent template for presenting peptidyl trp indole and tyr phenol.A combined GD, fluorescence spectroscopic study and ESI-MS reveals the roles of metal ion-indole interactions.The results indicate that the receptor (EWY) has a good selective recognition property for transition metal ions in water.