反流性食管炎与幽门螺杆菌感染的关系

摘要

目的 观察反流性食管炎(reflux esophagitis,RE)与幽门螺杆菌(Helicobacter pylori,Hp)感染的关系.方法 收集经过胃镜确诊的RE患者235例及慢性浅表性胃炎患者235例,行反流性疾病问卷(reflux diagnostic questionnaire,RDQ)调查,并在内镜下取两块黏膜组织采用快速尿素酶试验结合病理学检查(Giemsa染色)判断Hp是否感染,比较两组患者RDQ分数及Hp感染情况.结果 两组人群平均年龄、性别比较,差异无统计学意义(P ＞0.05)；RE组患者的RDQ为(12.8±0.5)分,慢性浅表性胃炎组的RDQ为(6.1±0.2)分,两组差异有统计学意义(P ＜0.01)；RE组患者的Hp(+)感染数为111(49.8％),慢性浅表性胃炎组Hp(+)感染数为124(52.8％),两组差异无统计学意义(P＞0.05).结论 反流性食管炎的发生与出门螺杆菌感染无明显关系.%Objective To investigate the relationship between Helicobacter pylori(Hp) and reflux esophagitis (RE). Methods Two hundred and thirty five patients with RE and 235 patients with chronic superficial gastritis diagnosed by endoscopy in Tongji Hospital were enrolled in the study. Reflux diagnostic questionnaire(RDQ) scale survey was performed; rapid urease Hp test and gastric mucosal pathology (Giemsa-staining) were examined on the biopsy tissue specemens. Results There were no significant differences in the mean age and gender between RE group and chronic superficial gastritis group (P >0.05). The RDQ score of RE group was significantly higher than that of chronic superficial gastritis group ( 12.8 ± 0. 5 ) vs (6. 1 ±0.2),(P<0.01). There were no differences in positive rate of Hp infection between two groups (49. 8% vs 52. 8% , P >0. 05). Conclusion Hp infection may be not related to reflux esopharitis.