血清β2-微球蛋白与系统性红斑狼疮疾病活动度及其肾脏损害的相关性

摘要

Objective:To explore the clinical significance of serum levels of β2-microglobulin and disease activity together with renal damage in systemic lupus erythematosus (SLE)patients.Methods:The levels of serum β2-microglobulin were measured by radioimmunoassay in 107 patients with SLE.Results:The levels of serum β2-microglobulin were significantly higher in active group than remisson group [(4.76±3.00) mg/L vs (2.45±1.17) mg/L],the concentrations of serum β2-microglobulin in lupus nephritis patients were significantly higher than non-lupus nephritis group [(3.94±3.07) mg/L vs (2.86±1.47) mg/L].The levels of serum β2-microglobulin were positively correlated with SLE disease activity index (SLEDAI)and 24 hours urine protein (respectively,r=0.632,r=0.225,P＜0.05).Conclusion:Serum β2-microglo bulin may associate with disease activity and renal damage in patients with SLE.%目的:探讨系统性红斑狼疮(SLE)患者血清β2-微球蛋白水平与疾病活动度及其肾脏损害的相关性及临床意义.方法:采用放射免疫法测定107例SLE患者血清β2-微球蛋白水平,观察其与病情活动指标及肾脏损害的相关性.结果:SLE疾病活动期患者血清β2-微球蛋白水平显著高于缓解期患者[0.76±3.00) mg/L vs(2.45±1.17) mg/L],狼疮肾炎组患者血清β2-微球蛋白水平显著高于非狼疮肾炎组[(3.92±2.85) mg/Lvs(2.63±1.25) mg/L],分别比较差异具有统计学意义(P＜0.05);血清β2-微球蛋白水平与SLE疾病活动性指数(SLEDAI)、24h尿蛋白呈正相关(分别为r=0.632,r =0.229,P＜0.05).结论:血清β2-微球蛋白与系统性红斑狼疮疾病活动及其肾脏损害相关.