难治性哮喘与肺炎支原体感染的关联研究

摘要

Objectives To investigate the relation of refractory asthma and Mycoplasma pneumoniae infection ( MP).Methods 45 patients of difficult asthma ( observation group) and 80 patients of bronchial asthma remission ( control group) hospitalized in our hospital from 2012 August to 2014 November were selected for the research, mycoplasma pneumonia IgM ( MP-IgM) antibody and serum total IgE levels of two groups were detected, through statistical analysis, correlation between the two diseases was ana-lyzed.Results The positive rate of MP-IgM antibody in observation group (66.7%) was significantly higher than the control group (33.8%);the difference was statistically significant (P<0.01).Serum total IgE level of MP-IgM positive patients with bronchial asthma was significantly higher than MP-IgM negative patients with bronchial asthma, two groups compared, the difference was sta-tistically significant (P<0.05).Conclusions MP infection and refractory asthma are closely related.%目的：探讨难治性支气管哮喘与肺炎支原体感染（ MP）发病的关系。方法选取我院2012年8月至2014年11月住院治疗的难治性支气管哮喘患者（观察组）45例及支气管哮喘缓解期患者（对照组）80例，检测两组血清肺炎支原体IgM（MP-IgM）抗体及血清总IgE水平，通过统计学分析两者的相关性。结果观察组MP-IgM抗体阳性率（66.7％）显著高于对照组（33.8％），差异显著，有统计学意义（P＜0.01；OR＝3.93，95％ CI：1.69～9.20）；MP-IgM阳性的支气管哮喘患者血清总IgE平均水平高于MP-IgM阴性的支气管哮喘患者，两组比较差异显著，有统计学意义（ P＜0.05）。结论肺炎支原体感染与难治性支气管哮喘可能有密切的关联。