Objective To investigate the gender differences in perinatal high-salt diet programming of blood pressure and salt sensitivity in offspring Sprague-Dawley rats and explore the mechanisms. Methods The rats were fed with high-salt diet (8% NaCl) or normal salt diet (1% NaCl) during the perinatal period. Body weight changes were monitored, and blood pressure and heart rate were measured by non-invasive tail-cuff methods in both male and female offspring rats. The components of renin-angiotensin-aldosterone system (RAAS) in both the serum and brain tissue, and hormones related with stress reaction were detected using radioimmunology methods. Results Perinatal high-salt diet did not affect adolescent blood pressure in both genders, but significantly increased salt sensitivity in male offspring rats. Perinatal high-salt diet also increased serum angiotensin II (ANG II) while decreased corticotropin-releasing hormone (CRH) and cortisol in male offsprings, as compared with the normal salt diet group. No similar results were found in the female offspring rats. Conclusion There is a significant gender difference in perinatal high-salt diet programming of offspring blood pressure salt sensitivity, and the mechanisms may involve the disturbance of the RAAS function and stress reaction.%目的 探讨围产期高盐饮食对子代Sprague-Dawley大鼠动脉血压及盐敏感性程控作用的性别差异及其可能机制.方法 围产期给予高盐饮食(8% NaCl)和正常饮食(1% NaCl),监测雄性及雌性子代体重发育,并采用无创性尾套法测量血压及心率变化；后给予各组子代高盐饮食14d观察其盐敏感性,并于测量结束后以放射免疫学方法检测血清及脑组织肾素-血管紧张素-醛固酮系统各成分及应激相关激素水平.结果 围产期高盐饮食对子代大鼠青春期动脉血压无显著影响,但显著提高雄性子代的盐敏感性,且雄性子代血清血管紧张素Ⅱ升高,而肾上腺皮质激素释放激素和皮质醇低于正常组,雌性子代则未观察到相同效应.结论 围产期高盐饮食对子代动脉血压盐敏感性具有程控作用,并具有显著的性别差异,其机制可能与子代肾素-血管紧张素-醛固酮系统功能异常及应激反应性变化有关.
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