冠心病合并糖尿病患者乙醛脱氢酶2基因多态性与高血压的关系

摘要

Objective To investigate the correlation of G487A polymorphism of aldehyde dehydrogenase-2 (ALDH2) gene with hypertension in patients with coronary heart disease complicated by type 2 diabetes. Methods This study was conducted among 167 patients with coronary heart disease complicated by diabetes mellitus. The polymorphisms of gene G487A ALDH2 were determined using polymerase chain reaction-restricted fragments length polymorphism technique (PCR-RFLP). According to the genotypes, the patients were divided into GG group (n=105) and GA/AA group (n=62), and the incidence of hypertension, risk factors of hypertension, systolic and diastolic pressures, and pulse pressure indexes were compared between the two groups. Multivariate logistic regression analysis was performed to adjust the effects of the confounding factors. Results The incidence of hypertension in GA/AA group was significantly higher than that in GG group (P0.05), and the former group showed a significantly greater differences between systolic and pulse pressure; the diastolic pressure was comparable between the two groups. Multivariate logistic regression analysis showed that GA/AA was associated with an increased risk of hypertension in synergy with high insulin level and insulin resistance. Conclusion ALDH2 gene G487A polymorphism may be associated with hypertension in patients with coronary heart disease complicated by type 2 diabetes, and the patients with an A allele have a greater risk of developing hypertension.%目的 探讨皖北地区冠心病合并糖尿病患者乙醛脱氢酶2(ALDH2)基因多态性与高血压的相关性.方法 筛选出皖北地区167例冠心病合并糖尿病患者为研究对象,应用聚合酶链式反应-限制性片段长度多态性方法(PCR-RFLP)分析ALDH2基因G487A多态性.按照ALDH2基因型分为2组:野生型组(n=105)和突变型组(n=62),比较两组间高血压的患病率、高血压的危险因素以及收缩压、舒张压、脉压等指标的差异.结果 冠心病合并糖尿病患者ALDH2基因突变型组高血压发生率高于野生型组(P＜0.05)；两组之间收缩压、脉压差明显大于野生型组,舒张压无明显差异.Logistic回归分析显示,ALDH2基因突变型增加了高血压的发生机率,与高胰岛素水平、胰岛素抵抗发挥协同作用.结论 ALDH2基因的突变与高血压存在相关性；携带A等位基因可能使冠心病合并糖尿病患者高血压发生的危险性增加.