以多浆膜腔积液为首发症状伴复杂染色体核型的多发性骨髓瘤一例并文献复习

摘要

Multiple myeloma(MM) is a kind of malignant colonial disease with heterogeneous clinical manifesta-tions including plasma cell neoplasia, accumulation of monoclonal immunoglobulin, hypogammaglobulinemia and hypercalcemia,renal insufficiency,anemia,osteolytic lesions,commonly referred as CRAB features. The diagnosis of MM traditionally required end-organ damage(CRAB features ) caused by the neoplastic clone of plasma cells. Here,we report an MM patient with polyserositis as initial symptom in order to improve the diagnosis of some atypi-cal MM patients.%多发性骨髓瘤(MM)是具有高度异质性的浆细胞恶性克隆性疾病,临床表现为单克隆免疫球蛋白聚集、低丙种球蛋白血症、高钙血症、肾损害、贫血及溶骨性病变,称为"CRAB".MM早期诊断对治疗方案的选择与疗效的评估具有一定的影响,符合MM典型临床表现及特征性实验室检查结果,包括骨髓形态、免疫分型、免疫固定电泳及相关异常基因,诊断较易.然而,对于首发症状及临床表现不典型的患者早期诊断存在一定困难.本文报道以多浆膜腔积液为首发症状的MM患者1例,并复习相关文献,提高MM的早期诊断率.