C/EBPβ蛋白影响维吾尔族妇女子宫颈鳞癌组织细胞增殖的研究

摘要

To explore the effect of C/EBPβ protein on the cell proliferation of cervical tissue of Uyghur women,we detected C/EBPβ and Ki-67protein level on cervical paraffin slice of Uyghur women in Xinjiang by immunohistochemistry method.and analyzed the expression and its significance.Results:C/EBPβ protein had low expression on cervical squamous cell carcinoma tissue and higher expression on chronic cervictis tissue.In contrast,Ki-67protein had high expression on cervical squamous cell carcinoma tissue and low expression on chronic cervictis tissue.In addition,C/EBPβ and Ki-67protein expression had negative correlation.C/EBPβ protein could inhibit the cell proliferation of cervical squamous cell carcinoma.%为了探讨C/EBPβ蛋白影响维吾尔族妇女子宫颈组织细胞增殖的作用.采用免疫组织化学方法对100例新疆维吾尔族妇女子宫颈组织标本石蜡切片检测C/EBPβ和Ki-67的表达情况,并对其表达及意义进行分析.结果发现C/EBPβ蛋白在子宫颈鳞癌组织中低表达,在慢性子宫颈炎组织中高表达；Ki-67蛋白在子宫颈鳞癌组织中高表达,在慢性子宫颈炎组织中低表达.C/EBPβ蛋白质与Ki-67蛋白质的表达呈现负相关性.由此可知,C/EBPβ蛋白可以抑制子宫颈鳞癌组织细胞的增殖.